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    Building Your Supplement Stack

    February 27, 20261 min readA. Singh, MDReviewed by D. Tran, MD, Internal Medicine

    Personalization Is Everything

    A supplement stack should be based on your individual needs, not a generic recommendation.

    Step 1: Get Baseline Labs

    Before starting any supplement, request these tests:

    • Vitamin D (25-OH) — optimal range: 40–60 ng/mL
    • Complete blood count — checks for anemia
    • Metabolic panel — kidney/liver function
    • Ferritin — iron stores (more accurate than serum iron)
    • B12 and folate — especially if vegetarian/vegan
    • Magnesium (RBC) — standard serum test is unreliable

    Step 2: Address Deficiencies First

    Fill documented gaps before adding "optimization" supplements:

    1. Deficient (<20 ng/mL vitamin D) → therapeutic dosing
    2. Insufficient (20–30 ng/mL) → maintenance dosing
    3. Optimal (40–60 ng/mL) → seasonal maintenance only

    Step 3: Goal-Based Additions

    For energy and focus:

    • Creatine monohydrate (5g daily) — well-studied, safe
    • B-complex — if levels are suboptimal

    For sleep quality:

    • Magnesium glycinate (200–400mg before bed)
    • Melatonin (0.5–1mg — lower is often better)

    For joint health:

    • Omega-3s (2000mg EPA/DHA)
    • Vitamin D (if deficient)

    For immune support:

    • Vitamin D + zinc + vitamin C
    • Elderberry (during cold season)

    Timing Matters

    • With breakfast: Vitamin D, B vitamins, iron (with vitamin C)
    • With dinner: Omega-3s, CoQ10 (fat-soluble)
    • Before bed: Magnesium, melatonin

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    1.Supplement Quality and Safety1.Which Supplements Actually Matter2.Building Your Supplement Stack
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